Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex-Reference-Cited by-同舟云学术

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Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Published:2024-08-16 Issue:1 Volume:7 Page:
ISSN:2399-3669
Container-title:Communications Chemistry
language:en
Short-container-title:Commun Chem

Author:

Hao Qi^ORCID,Rathinaswamy Manoj K.,Klinge Kelly L.,Bratkowski Matthew^ORCID,Mafi Amirhossein,Baumgartner Christina K.,Hamel Keith M.,Veits Gesine K.,Jain Rinku,Catalano Claudio^ORCID,Fitzgerald Mark,Hird Alexander W.,Park Eunice,Vora Harit U.,Henderson James A.,Longenecker Kenton,Hutchins Charles W.,Qiu Wei,Scapin Giovanna,Sun Qi,Stoll Vincent S.,Sun Chaohong,Li Ping,Eaton Dan^ORCID,Stokoe David,Fisher Stewart L.,Nasveschuk Christopher G.^ORCID,Paddock Marcia,Kort Michael E.

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s42004-024-01263-7.pdf

Reference60 articles.

1. Stanford, S. M. & Bottini, N. Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders. Nat. Rev. Drug Discov. 22, 273–294 (2023).

2. Manguso, R. T. et al. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target. Nature 547, 413–418 (2017).

3. LaFleur, M. W. et al. A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system. Nat. Commun. 10, 1668 (2019).

4. Baumgartner, C. K. et al. The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature, https://doi.org/10.1038/s41586-023-06575-7 (2023).

5. Kramer, L. T. & Zhang, X. Expanding the landscape of E3 ligases for targeted protein degradation. Curr. Res. Chem. Biol. 2, 100020 (2022).

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