Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV‐negative tumors is an indicator of poor prognosis-Reference-Cited by-同舟云学术

Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV‐negative tumors is an indicator of poor prognosis

Published:2019-01-30 Issue:10 Volume:144 Page:2465-2477
ISSN:0020-7136
Container-title:International Journal of Cancer
language:en
Short-container-title:Int. J. Cancer

Author:

Huebbers Christian U.¹^ORCID,Verhees Femke²,Poluschkin Leonard¹,Olthof Nadine C.²³,Kolligs Jutta¹,Siefer Oliver G.¹,Henfling Mieke³,Ramaekers Frans C.S.³,Preuss Simon F.⁴,Beutner Dirk⁵,Seehawer Julia⁴,Drebber Uta⁶,Korkmaz Yüksel⁷⁸⁹,Lam Wan L.¹⁰,Vucic Emily A.¹⁰,Kremer Bernd²,Klussmann Jens P.⁴,Speel Ernst‐Jan M.¹¹

Affiliation:

1. Jean‐Uhrmacher‐Institute for Otorhinolaryngological ResearchUniversity of Cologne Cologne Germany

2. Department of Otorhinolaryngology and Head and Neck SurgeryGROW ‐ School for Oncology and Developmental Biology, Maastricht University Medical Centre Maastricht the Netherlands

3. Department of Molecular Cell BiologyGROW ‐ School for Oncology and Developmental Biology, Maastricht University Medical Centre Maastricht the Netherlands

4. Department of OtorhinolaryngologyHead and Neck Surgery, University Hospital of Cologne Cologne Germany

5. Department of OtorhinolaryngologyHead and Neck Surgery, University of Göttingen Germany

6. Institute for Pathology, University Hospital of Cologne Cologne Germany

7. Institute for Experimental Dental Research and Oral Musculoskeletal Biology, University Hospital of Cologne Cologne Germany

8. Department I of AnatomyUniversity Hospital of Cologne Cologne Germany

9. Center for BiochemistryUniversity Hospital of Cologne Cologne Germany

10. Department of Integrative OncologyBritish Columbia Cancer Research Centre Vancouver Canada

11. Department of PathologyGROW ‐ School for Oncology and Developmental Biology, Maastricht University Medical Centre Maastricht the Netherlands

Funder

Jean-Uhrmacher-Society

KoelnFortune, University of Cologne

Jean Uhrmacher Foundation

Stiftung Tumorforschung Kopf-Hals

Publisher

Wiley

Subject

Cancer Research,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.31954

Reference49 articles.

1. The molecular biology of head and neck cancer

2. HPV and cancer of the oral cavity

3. Comprehensive Analysis of HPV16 Integration in OSCC Reveals No Significant Impact of Physical Status on Viral Oncogene and Virally Disrupted Human Gene Expression

4. Genetic Signatures of HPV-related and Unrelated Oropharyngeal Carcinoma and Their Prognostic Implications

5. Analysis of The Cancer Genome Atlas sequencing data reveals novel properties of the human papillomavirus 16 genome in head and neck squamous cell carcinoma

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