Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma

Author:

Wan Meixuan,Yang Xinxin,He Lin,Meng Hongxue

Abstract

AbstractLaryngeal cancer ranks as the second most prevalent upper airway malignancy, following Lung cancer. Although some progress has been made in managing laryngeal cancer, the 5-year survival rate is disappointing. The gradual increase in the incidence of second primary tumors (SPTs) plays a crucial role in determining survival outcomes during long-term follow-up, and the esophagus was the most common site with a worse prognosis. In clinical practice, the treatment of esophageal second primary tumors (ESPT) in patients with laryngeal squamous cell carcinoma (LSCC) has always been challenging. For patients with synchronous tumors, several treatment modalities, such as radiotherapy, chemotherapy and potentially curative surgery are necessary but are typically poorly tolerated. Secondary cancer therapy options for metachronous patients are always constrained by index cancer treatment indications. Therefore, understanding the clonal origin of the second primary tumor may be an important issue in the treatment of patients. LSCC cells demonstrate genetic instability because of two distinct aetiologies (human papillomavirus (HPV)-negative and HPV-positive) disease. Various etiologies exhibit distinct oncogenic mechanisms, which subsequently impact the tissue microenvironment. The condition of the tissue microenvironment plays a crucial role in determining the destiny and clonal makeup of mutant cells during the initial stages of tumorigenesis. This review focuses on the genetic advances of LSCC, the current research status of SPT, and the influence of key carcinogenesis of HPV-positive and HPV-negative LSCC on clonal evolution of ESPT cells. The objective is to gain a comprehensive understanding of the molecular basis underlying the clonal origins of SPT, thereby offering novel perspectives for future investigations in this field.

Funder

National Nature Science Foundation of China

Postdoctoral Scientific. Research Developmental Fund of Heilongjiang Province

N10 Found project of Harbin Medical University Cancer Hospital

Outstanding Youth Foundation of Harbin Medical University Cancer Hospital

National Nature Science Foundation of Heilongjiang Province

Special funds of central finance to support the development of local University

Wu-Jieping Medical Foundation

Beijing Medical Award Foundation

Hai Yan Youth Fund of Harbin Medical University Cancer Hospital

Fund amental Research Funds for the Provincial Universities

Natural Science Foundation of Heilongjiang Province

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Infectious Diseases,Oncology,Epidemiology

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