Identifying Ferroptosis‐Related Genes Associated with Weight Loss Outcomes and Regulation of Adipocyte Microenvironment

Author:

Li Wanyang1ORCID,Xu Hanyuan1,Li Yao2,Shi Xiaodong1,Ma Zhaotian34,Yang Fan35,Chen Wei1

Affiliation:

1. Department of Clinical Nutrition Chinese Academy of Medical Sciences‐Peking Union Medical College Peking Union Medical College Hospital (Dongdan campus) No.1 Shuaifuyuan Wangfujing Dongcheng District Beijing 100730 China

2. College of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Shandong 250355 China

3. College of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China

4. Institute of Ethnic Medicine Beijing University of Traditional Chinese Medicine Beijing 100029 China

5. National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese Medicine Beijing 100029 China

Abstract

ScopeThe study is about the influence of ferroptosis‐related genes combined with the immune microenvironment exerted on weight control outcomes and systematic analysis.Methods and resultsSubcutaneous adipose tissue (sWAT) samples from 11 subjects with good outcome and 10 subjects with poor outcome in weight management are obtained from the Gene Expression Omnibus database. The results are validated in vivo in animal models with different weight loss outcomes. The CIBERSORT algorithm is used to evaluate the differences in immune cell infiltration in each sample. Patients with poor outcome have higher levels of ferroptosis in the adipose tissue. Remarkable differences in cytokine production, nuclear factor kappa‐B(NF‐κB) transcription factor activity, leukocyte migration involved in the inflammatory response, and other biological processes are also observed compared to that in the well‐controlled group. Aldo‐keto reductase family 1‐member C1(AKR1C1), nuclear receptor coactivator 4(NCOA4), and glutamate‐cysteine ligase catalytic subunit(GCLC) are identified as core predictive markers and their expression patterns are confirmed in animal models.ConclusionsFerroptosis and its mediated inflammation play an important role in long‐term weight control, and analyses of the role of ferroptosis‐related genes(FRGs) in weight control may provide new potential therapeutic targets for long‐term weight control. Anti‐inflammatory diets that mitigate inflammatory responses and affect ferroptosis may be considered in the future to improve weight control.

Publisher

Wiley

Subject

Food Science,Biotechnology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3