Synthesis of 5‐Trifluoromethyl‐1,4‐dihydro‐1,2,4‐triazines via Base‐mediated [3+3] Cycloaddition of Nitrile Imines and CF<sub>3</sub>‐Imidoyl Sulfoxonium Ylides-Reference-Cited by-同舟云学术

Synthesis of 5‐Trifluoromethyl‐1,4‐dihydro‐1,2,4‐triazines via Base‐mediated [3+3] Cycloaddition of Nitrile Imines and CF₃‐Imidoyl Sulfoxonium Ylides

Published:2023-04-18 Issue:9 Volume:365 Page:1521-1525
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Sun Yue¹,Ling Sihao¹,Duan Yubo¹,Li Jingxian¹,Chen Zhengkai¹^ORCID,Wu Xiao‐Feng²³^ORCID

Affiliation:

1. Department of Chemistry Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province Zhejiang Sci-Tech University Hangzhou 310018 China

2. Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Liaoning China

3. Leibniz-Institut für Katalyse e. V. Albert-Einstein-Straβe 29a 18059 Rostock Germany

Abstract

AbstractAn approach for the construction of 5‐trifluoromethyl‐1,4‐dihydro‐1,2,4‐triazines has been developed via base‐mediated [3+3] cycloaddition of in‐situ generated nitrile imines and CF3‐substituted imidoyl sulfoxonium ylides. The metal‐free protocol is characterized by readily available starting materials, mild conditions, a broad substrate scope, high efficiency, good synthetic prospect, and scalability.

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Funder

K. C. Wong Education Foundation

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202300162

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3. Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents