Affiliation:
1. Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing College of Materials Science and Engineering Huaqiao University Xiamen 361021 People's Republic of China
Abstract
Abstract2‐Iminothiazolidin‐4‐one, 5‐ethylidenethiazolidin‐4‐one, and thiazolidine‐4‐thione are all medicinally relevant structures. In this work, a NaSO2CF3‐promoted [2+2+1] cascade annulation reaction of CF3‐imidoyl sulfoxonium ylides and isothiocyanates was reported to synthesize a variety of decorated thiazolidine‐4‐thiones in 35–91% yields with exclusive stereoselectivity. The gram‐scale reaction and further chemoselective S‐alkylations demonstrated the synthetic utilities of this transformation.
Funder
National Natural Science Foundation of China