Rh(III)‐Catalyzed Cascade Cyclization of 2‐Aryl‐3H‐indoles and CF3‐Imidoyl Sulfoxonium Ylides Toward Trifluoroacetimidoyl‐Substituted 11H‐Isoindolo[2,1‐a]indoles-Reference-Cited by-同舟云学术

Rh(III)‐Catalyzed Cascade Cyclization of 2‐Aryl‐3H‐indoles and CF₃‐Imidoyl Sulfoxonium Ylides Toward Trifluoroacetimidoyl‐Substituted 11H‐Isoindolo[2,1‐a]indoles

Published:2023-11-06 Issue:22 Volume:365 Page:3855-3860
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Yang Zuguang¹,Li Pinyi¹,Chen Zhengkai¹^ORCID,Wu Xiao‐Feng²³^ORCID

Affiliation:

1. Department of Chemistry Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province Zhejiang Sci-Tech University Hangzhou 310018 People's Republic of China

2. Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023, Liaoning People's Republic of China

3. Leibniz-Institut für Katalyse e. V. Albert-Einstein-Straβe 29a 18059 Rostock Germany

Abstract

AbstractA rhodium(III)‐catalyzed C−H activation/[4+1] annulation of 2‐aryl‐3H‐indoles and CF3‐substituted imidoyl sulfoxonium ylides (TFISYs) has been achieved, producing a wide variety of trifluoroacetimidoyl‐substituted 11H‐isoindolo[2,1‐a]indoles in 51–86% yields. The cascade reaction involves C−H imidoylmethylation, tautomerization and AgOAc‐mediated C−N bond formation sequence. The reaction could be scaled up to 2 mmol scale.

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202301036

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