Affiliation:
1. Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences and the Fifth Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong 511436 People's Republic of China
Abstract
AbstractWe report herein a chiral CpXRh(III)‐catalyzed domino cyclization/C3‐arylation process using 2‐alkynylanilines and 1‐diazonaphthoquinones as viable substrates, delivering indole‐based derivatives endowed with axial chirality. The method features high enantioselectivity, broad substrate scope, and robust functional group tolerance. Subsequent functionalization of the synthesized scaffolds underlines the practicality of this approach in the design of indole‐derivated axially chiral frameworks, demonstrating its substantial promise in synthetic and medicinal chemistry applications.
Funder
National Natural Science Foundation of China