Approaches to Synthesis and Isolation of Enantiomerically Pure Biologically Active Atropisomers-Reference-Cited by-同舟云学术

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Approaches to Synthesis and Isolation of Enantiomerically Pure Biologically Active Atropisomers

Published:2022-10-04 Issue:20 Volume:55 Page:2938-2948
ISSN:0001-4842
Container-title:Accounts of Chemical Research
language:en
Short-container-title:Acc. Chem. Res.

Author:

Carlsson Anna-Carin C.¹^ORCID,Karlsson Staffan¹^ORCID,Munday Rachel H.²,Tatton Matthew R.³^ORCID

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca Gothenburg, SE-431 83 Mölndal, Sweden

2. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca Macclesfield, Macclesfield SK10 2NA, United Kingdom

3. Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca Macclesfield, Macclesfield SK10 2NA, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

General Medicine,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.2c00513

Reference51 articles.

1. Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRASG12C Inhibitors

2. Exploration of a Nitromethane-Carbonylation Strategy during Route Design of an Atropisomeric KRASG12C Inhibitor

3. Recent encounters with atropisomerism in drug discovery

4. The DFT study on racemisation of atropisomeric biaryls

5. Revealing Atropisomer Axial Chirality in Drug Discovery

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1. Simultaneous construction of inherent and axial chirality by cobalt-catalyzed enantioselective C-H activation of calix[4]arenes;Nature Communications;2024-09-03

2. Enantioselective electrochemical and photochemical synthesis of atropisomers;Trends in Chemistry;2024-09

3. Synthesis of N–N Axially Chiral Pyrrolyl-oxoisoindolin via Isothiourea-Catalyzed Acylative Dynamic Kinetic Resolution;Organic Letters;2024-07-18

4. Atroposelective N–N Axes Synthesis via Electrochemical Cobalt Catalysis;Organic Letters;2024-06-12

5. Carbene-Catalyzed Atroposelective Construction of Chiral Diaryl Ethers;The Journal of Organic Chemistry;2024-05-13

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