Deuterated active pharmaceutical ingredients: A science-based proposal for synthesis, analysis, and control. Part 1: Framing the problem-Reference-Cited by-同舟云学术

Deuterated active pharmaceutical ingredients: A science-based proposal for synthesis, analysis, and control. Part 1: Framing the problem

Published:2019-06-18 Issue:11 Volume:62 Page:690-694
ISSN:0362-4803
Container-title:Journal of Labelled Compounds and Radiopharmaceuticals
language:en
Short-container-title:J Label Compd Radiopharm

Author:

Czeskis Boris¹,Elmore Charles S.²^ORCID,Haight Anthony³,Hesk David⁴,Maxwell Brad D.⁵^ORCID,Miller Scott A.⁶,Raglione Thomas⁶,Schildknegt Klaas⁷,Traverse John F.⁸,Wang Peng⁸

Affiliation:

1. Eli Lilly and Company; Indianapolis Indiana

2. AstraZeneca; Gothenburg Sweden

3. AbbVie Inc.; North Chicago; Illinois

4. Research Triangle Institute; Research Triangle Park; North Carolina

5. Vertex Pharmaceuticals Incorporated; Boston Massachusetts

6. Bristol-Myers Squibb; New Brunswick New Jersey

7. Pfizer Inc.; Groton Connecticut

8. Celgene Corporation; Summit New Jersey

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology, Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jlcr.3743/fullpdf

Reference8 articles.

1. Using Deuterium in Drug Discovery: Leaving the Label in the Drug;Gant;J. Med. Chem.,2014

2. The deuterium switcheroo;Halford;Chemical & Engineering News,2016

3. First deuterated drug approved;Schmidt;Nature Biotechnology,2017

4. The Absolute Optical Specificity of Monoamine Oxidase;Belleau;J. Am. Chem. Soc.,1960

5. Effect of Deuterium Substitution in Sympathomimetic Amines on Adrenergic Responses;Belleau;Science,1961

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