Deuterium in drug discovery: progress, opportunities and challenges
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.nature.com/articles/s41573-023-00703-8.pdf
Reference191 articles.
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2. Belleau, B., Burba, J., Pindell, M. & Reiffenstein, J. Effect of deuterium substitution in sympathomimetic amines on adrenergic responses. Science 133, 102–104 (1961).
3. Elison, C., Rapoport, H., Laursen, R. & Elliott, H. W. Effect of deuteration of N-CH3 group on potency and enzymatic N-demethylation of morphine. Science 134, 1078–1079 (1961).
4. Agranat, I., Caner, H. & Caldwell, J. Putting chirality to work: the strategy of chiral switches. Nat. Rev. Drug Discov. 1, 753–768 (2002).
5. Vitale, G. Deuterium drugs attract investment. CEN Glob. Enterp. 101, 10–10 (2023).
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