Synthesis and Biological Evaluation of Imidazole-Bearing α-Phosphonocarboxylates as Inhibitors of Rab Geranylgeranyl Transferase (RGGT)-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Imidazole-Bearing α-Phosphonocarboxylates as Inhibitors of Rab Geranylgeranyl Transferase (RGGT)

Published:2018-03-02 Issue:8 Volume:13 Page:842-851
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Joachimiak Łukasz¹^ORCID,Marchwicka Aleksandra²,Gendaszewska-Darmach Edyta²,Błażewska Katarzyna M.¹^ORCID

Affiliation:

1. Faculty of Chemistry; Lodz University of Technology; Institute of Organic Chemistry; Żeromskiego Str. 116 90-924 Łódź Poland

2. Faculty of Biotechnology and Food Sciences; Lodz University of Technology, Institute of Technical Biochemistry; Stefanowskiego Str. 4/10 90-924 Łódź Poland

Funder

Narodowe Centrum Nauki

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201700791/fullpdf

Reference30 articles.

1. The Rab family of proteins: 25 years on

2. RAB11-mediated trafficking in host–pathogen interactions

3. Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design

4. Prenyltransferase inhibitors: treating human ailments from cancer to parasitic infections

5. Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation

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