Optimization of Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase Based on Group Efficiency Analysis-Reference-Cited by-同舟云学术

Optimization of Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase Based on Group Efficiency Analysis

Published:2015-10-21 Issue:1 Volume:11 Page:38-42
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Hung Alvin W.¹²,Silvestre H. Leonardo³,Wen Shijun¹,George Guillaume P. C.¹,Boland Jennifer¹,Blundell Tom L.³,Ciulli Alessio¹⁴,Abell Chris¹

Affiliation:

1. Department of Chemistry; University of Cambridge; Lensfield Rd Cambridge CB2 1EW UK

2. Experimental Therapeutic Centre; A-STAR; 11 Biopolis Way Singapore 138667 Singapore

3. Department of Biochemistry; University of Cambridge; 80 Tennis Court Rd Cambridge CB2 1GA UK

4. Division of Biological Chemistry & Drug Discovery; College of Life Sciences; James Black Centre; University of Dundee; Dow Street Dundee DD1 5EH UK

Funder

Bill & Melinda Gates Foundation

UK Biotechnology and Biological Sciences Research Council

Fundação para a Ciência e Tecnologia (FCT), Portugal

Homerton College, Cambridge

Agency for Science, Technology and Research (A*STAR), Singapore

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference22 articles.

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3. The role of ligand efficiency metrics in drug discovery

4. Group Efficiency: A Guideline for Hits-to-Leads Chemistry

5. Probing Hot Spots at Protein−Ligand Binding Sites: A Fragment-Based Approach Using Biophysical Methods

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