Probing Hot Spots at Protein−Ligand Binding Sites: A Fragment-Based Approach Using Biophysical Methods-Reference-Cited by-同舟云学术

Probing Hot Spots at Protein−Ligand Binding Sites: A Fragment-Based Approach Using Biophysical Methods

Published:2006-07-08 Issue:16 Volume:49 Page:4992-5000
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ciulli Alessio¹,Williams Glyn¹,Smith Alison G.¹,Blundell Tom L.¹,Abell Chris¹

Affiliation:

1. University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, Astex Therapeutics Ltd., 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, and Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060490r

Reference50 articles.

1. A simple physical model for binding energy hot spots in protein-protein complexes

2. Unraveling hot spots in binding interfaces: progress and challenges

3. Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

4. Druggability Indices for Protein Targets Derived from NMR-Based Screening Data

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