A Minimalist Approach to the Design of Complexity-Enriched Bioactive Small Molecules: Discovery of Phenanthrenoid Mimics as Antiproliferative Agents-Reference-Cited by-同舟云学术

A Minimalist Approach to the Design of Complexity-Enriched Bioactive Small Molecules: Discovery of Phenanthrenoid Mimics as Antiproliferative Agents

Published:2018-07-19 Issue:16 Volume:13 Page:1732-1740
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Alonso Fernando¹²,Quezada María Josefina³⁴,Gola Gabriel F.¹²,Richmond Victoria¹²,Cabrera Gabriela M.¹²,Barquero Andrea A.³⁴,Ramírez Javier A.¹²^ORCID

Affiliation:

1. Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales; Universidad de Buenos Aires, Ciudad Universitaria; Ciudad Autónoma de Buenos Aires C1428EGA Argentina

2. CONICET - Universidad de Buenos Aires; Unidad de Microanálisis y Métodos Físicos Aplicados a Química Orgánica (UMYMFOR), Ciudad Universitaria; Ciudad Autónoma de Buenos Aires C1428EGA Argentina

3. CONICET - Universidad de Buenos Aires; Instituto de Quimica Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Ciudad Universitaria; Ciudad Autónoma de Buenos Aires C1428EGA Argentina

4. Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales; Universidad de Buenos Aires, Ciudad Universitaria; Ciudad Autónoma de Buenos Aires C1428EGA Argentina

Funder

Fondo para la Investigación Científica y Tecnológica

Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201800295/fullpdf

Reference53 articles.

1. A comparative analysis of the molecular topologies for drugs, clinical candidates, natural products, human metabolites and general bioactive compounds

2. A perspective on multi‐target drug discovery and design for complex diseases

3. Is poor research the cause of the declining productivity of the pharmaceutical industry? An industry in need of a paradigm shift

4. Target-based drug discovery: is something wrong?

5. A critique of the molecular target-based drug discovery paradigm based on principles of metabolic control: Advantages of pathway-based discovery

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development of an Improved Guanidine‐Based Rac1 Inhibitor with in vivo Activity against Non‐Small Cell Lung Cancer;ChemMedChem;2021-01-25

2. Construction of Highly Functionalized Piperazinones via Post-Ugi Cyclization and Diastereoselective Nucleophilic Addition;The Journal of Organic Chemistry;2020-04-30