Construction of Highly Functionalized Piperazinones via Post-Ugi Cyclization and Diastereoselective Nucleophilic Addition

Author:

Tripathi Shashank12,Ambule Mayur D.12,Srivastava Ajay Kumar12ORCID

Affiliation:

1. Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow 226031, India

2. Chemical Sciences Division, Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India

Funder

Council of Scientific and Industrial Research

Science and Engineering Research Board

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference53 articles.

1. aPlewe, M.; Whitby, L.; Mccormack, K.; Henkel, G.; Brown, E.; Boger, D.; Sokolova, N.; Reddy, V. Compounds for the treatment of arenavirus infection. Patent WO 2016/160677 A1, October 6, 2016.

2. bSofia, M. J.; Kakarla, R.; Liu, J.; Naduthambi, D.; Mosley, R.; Steuer, H. M. Compounds Patent US 2012/0202794 A1, August 9, 2012.

3. cHamilton, A. D.; Sebti, S.; Peng, H. Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment. Patent WO 03/017939 A2, March 6, 2003.

4. Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives

5. Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders

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