Development of an Improved Guanidine‐Based Rac1 Inhibitor with in vivo Activity against Non‐Small Cell Lung Cancer-Reference-Cited by-同舟云学术

Development of an Improved Guanidine‐Based Rac1 Inhibitor with in vivo Activity against Non‐Small Cell Lung Cancer

Published:2021-01-25 Issue:6 Volume:16 Page:1011-1021
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Ciarlantini Matías S.¹,Barquero Andrea²³,Bayo Juan⁴,Wetzler Diana²³,Dodes Traian Martín M.²³,Bucci Hernán A.²³,Fiore Esteban J.⁴,Gandolfi Donadío Lucía¹⁵,Defelipe Lucas²³,Turjanski Adrián²³,Ramírez Javier A.⁶⁷,Mazzolini Guillermo⁴⁸,Comin Maria J.¹⁵^ORCID

Affiliation:

1. Departamento de Ingredientes Activos y Biorrefinerías Instituto Nacional de Tecnología Industrial Av. General Paz 5445 B1650WAB San Martin Buenos Aires Argentina

2. Departamento de Química Biológica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Ciudad Universitaria C1428EGA Ciudad Autónoma de Buenos Aires Argentina

3. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)- Universidad de Buenos Aires Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN). Ciudad Universitaria C1428EGA Ciudad Autónoma de Buenos Aires Argentina

4. Gene Therapy Laboratory Instituto de Investigaciones en Medicina Traslacional Facultad de Ciencias Biomédicas Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Universidad Austral B1630FHB Derqui-Pilar Argentina

5. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Av. General Paz 5445 B1650WAB San Martin, Buenos Aires Argentina

6. Departamento de Química Orgánica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Ciudad Universitaria C1428EGA Ciudad Autónoma de Buenos Aires Argentina

7. Unidad de Microanálisis y Métodos Físicos Aplicados a Química Orgánica (UMYMFOR) Ciudad Universitaria C1428EGA Ciudad Autónoma de Buenos Aires Argentina

8. Liver Unit Hospital Universitario Austral B1629AHJ Derqui-Pilar, Buenos Aires Argentina

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000763

Reference52 articles.

1. Mammalian Rho GTPases: new insights into their functions from in vivo studies

2. The Rac GTPase in Cancer: From Old Concepts to New Paradigms

3. The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic

4. Hallmarks of Cancer: The Next Generation

5. Regulating Rho GTPases and their regulators

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