Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5-Reference-Cited by-同舟云学术

Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5

Published:2017-06-12 Issue:13 Volume:12 Page:1033-1044
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Wang Hezhen¹,Huwaimel Bader¹,Verma Kshitij¹,Miller James²,Germain Todd M.³,Kinarivala Nihar¹,Pappas Dimitri³,Brookes Paul S.²,Trippier Paul C.¹⁴^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences; Texas Tech University Health Sciences Center, School of Pharmacy; Amarillo TX 79106 USA

2. Department of Anesthesiology; University of Rochester Medical Center; Rochester NY 14642 USA

3. Department of Chemistry and Biochemistry; Texas Tech University; Lubbock TX 79409 USA

4. Center for Chemical Biology, Department of Chemistry and Biochemistry; Texas Tech University; Lubbock TX 79409 USA

Funder

Texas Tech University Health Sciences Center

Kingdom of Saudi Arabia Cultural Mission to the U.S.A

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference43 articles.

1. Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II

2. Biochemical, physiological and medical aspects of ubiquinone function

3. Mitochondrial complex II, a novel target for anti-cancer agents

4. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

5. Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation

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