Preventing mitochondrial reverse electron transport as a strategy for cardioprotection-Reference-Cited by-同舟云学术

Preventing mitochondrial reverse electron transport as a strategy for cardioprotection

Published:2023-08-28 Issue:1 Volume:118 Page:
ISSN:1435-1803
Container-title:Basic Research in Cardiology
language:en
Short-container-title:Basic Res Cardiol

Author:

Prag Hiran A.^ORCID,Murphy Michael P.^ORCID,Krieg Thomas^ORCID

Abstract

AbstractIn the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex I in mitochondria is a crucial trigger for damage during ischaemia/reperfusion (I/R) injury. Here we outline the necessary conditions for superoxide production by RET at complex I and how it can occur during reperfusion. In addition, we explore various pathways that are implicated in generating the conditions for RET to occur and suggest potential therapeutic strategies to target RET, aiming to achieve cardioprotection.

Funder

British Heart Foundation

Medical Research Council

Wellcome Trust

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://link.springer.com/content/pdf/10.1007/s00395-023-01002-4.pdf

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