Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology
Link
http://www.nature.com/articles/cddis2015110.pdf
Reference57 articles.
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3. Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D et al. Crystal structure of mitochondrial respiratory membrane protein complex II. Cell 2005; 121: 1043–1057.
4. Iverson TM . Catalytic mechanisms of complex II enzymes: a structural perspective. Biochim Biophys Acta 2013; 1827: 648–657.
5. Huang LS, Sun G, Cobessi D, Wang AC, Shen JT, Tung EY et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J Biol Chem 2006; 281: 5965–5972.
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