What Are We Missing? The Detergent Triton X‐100 Added to Avoid Compound Aggregation Can Affect Assay Results in an Unpredictable Manner-Reference-Cited by-同舟云学术

What Are We Missing? The Detergent Triton X‐100 Added to Avoid Compound Aggregation Can Affect Assay Results in an Unpredictable Manner

Published:2017-08-23 Issue:17 Volume:12 Page:1419-1423
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Ehlert Fabian G. R.¹,Linde Kerstin¹,Diederich Wibke E.¹^ORCID

Affiliation:

1. Zentrum für Tumor- und Immunbiologie und Institut für Pharmazeutische ChemiePhilipps-Universität Marburg Hans-Meerwein-Straße 3 35043 Marburg Germany

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201700329

Reference25 articles.

1. A Specific Mechanism of Nonspecific Inhibition

2. A detergent-based assay for the detection of promiscuous inhibitors

3. High-throughput assays for promiscuous inhibitors

4. An Aggregation Advisor for Ligand Discovery

5. Effect of Detergent on “Promiscuous” Inhibitors

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antiviral Drug Discovery with an Optimized Biochemical Dengue Protease Assay: Improved Predictive Power for Antiviral Efficacy;2024-06-06

2. Alternate recognition by dengue protease: Proteolytic and binding assays provide functional evidence beyond an induced-fit;Biochimie;2024-06

3. Alternate recognition by dengue protease: Proteolytic and binding assays provide functional evidence beyond an induced-fit;2024-04-15

4. Unraveling the unexpected aggregation behavior of Pyrazole-Based compounds Targeting Mycobacterium tuberculosis UDP-Galactopyranose mutase;Bioorganic & Medicinal Chemistry;2023-10

5. Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteases;European Journal of Medicinal Chemistry;2022-10