Synthesis and Opioid Activity of Tyr1-ψ[(Z)CF=CH]-Gly2and Tyr1-ψ[(S)/(R)-CF3CH-NH]-Gly2Leu-enkephalin Fluorinated Peptidomimetics

Author:

Karad Somnath Narayan1,Pal Mohan1,Crowley Rachel S.1,Prisinzano Thomas E.1ORCID,Altman Ryan A.1ORCID

Affiliation:

1. Department of Medicinal Chemistry; The University of Kansas; 1251 Wescoe Hall Drive Lawrence Kansas 66045 USA

Funder

National Institute on Drug Abuse

National Institute of General Medical Sciences

National Institutes of Health

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference61 articles.

1. Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies

2. The Latest Prescription Trends for Controlled Prescription Drugs, 2015 www.drugabuse.gov/news-events/meetings-events/2015/09/latest-prescription-trends-controlled-prescription-drugs

3. Endogenous opiates and behavior: 2014

4. Trends in Drug-Poisoning Deaths Involving Opioid Analgesics and Heroin: United States, 1999-2012 2014 www.cdc.gov/nchs/data/hestat/drug_poisoning/drug_poisoning.htm

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