Stapling of leu-enkephalin analogs with bifunctional reagents for prolonged analgesic activity-Reference-Cited by-同舟云学术

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Stapling of leu-enkephalin analogs with bifunctional reagents for prolonged analgesic activity

Published:2024 Issue:22 Volume:60 Page:3023-3026
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Kijewska Monika¹^ORCID,Wołczański Grzegorz¹^ORCID,Kosson Piotr²,Wieczorek Robert¹,Lisowski Marek¹,Stefanowicz Piotr¹

Affiliation:

1. Faculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland

2. Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warszawa, Poland

Abstract

The design and synthesis of leu-enkephalin analogs by replacing the glycine residues with N-(2-thioethyl)glycines and opening the cyclisation potential is presented.

Funder

Uniwersytet Wrocławski

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC06345C

Reference58 articles.

1. 6 Development of Receptor-Specific Opioid Peptide Analogues

2. Anti-Apoptotic Effect of Synthetic Leu-Enkephalin Dalargin on Rat Leukocytes in Cold Stress Model in Vivo

3. Delta opioid peptide (D-ALA 2, D-LEU 5) enkephalin: linking hibernation and neuroprotection

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1. Photochemical Transformations of Peptides Containing the N-(2-Selenoethyl)glycine Moiety;ACS Omega;2024-03-29

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