Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression-Reference-Cited by-同舟云学术

Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression

Published:2024-05-29 Issue:11 Volume:67 Page:9173-9193
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vu Loan Y.¹,Luo Dan¹²,Johnson Kai¹,Denehy Emily D.³,Songrady Judy C.¹,Martin Jocelyn³,Trivedi Riya¹,Alsum Alexia R.¹,Shaykin Jakob D.³,Chaudhary Chhabi Lal¹²,Woloshin Eric J.¹,Kornberger Lindsay¹,Bhuiyan Nazmul¹²,Parkin Sean⁴,Jiang Qianru⁵,Che Tao⁵,Alilain Warren⁶⁷,Turner Jill R.¹,Bardo Michael T.³,Prisinzano Thomas E.¹²

Affiliation:

1. Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States

2. Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, United States

3. Department of Psychology, University of Kentucky, Lexington, Kentucky 40536, United States

4. Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States

5. Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, Missouri 63110, United States

6. Spinal Cord and Brain Injury Research Center (SCoBIRC), College of Medicine, University of Kentucky, Lexington, Kentucky 40536, United States

7. Department of Neuroscience, University of Kentucky, Lexington, Kentucky 40536, United States

Funder

National Center for Advancing Translational Sciences

National Institute on Drug Abuse

National Institute of General Medical Sciences

Kentucky Medical Services Foundation Endowed Chair in Pharmacy

University of Kentucky Neuroscience Research Priority Area and Substance Use Research Priority Area

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00333

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4. Opioid Receptors

5. Opioid receptor subtypes: fact or artifact?