Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound-Reference-Cited by-同舟云学术

Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound

Published:2012-01-20 Issue:3 Volume:7 Page:406-414
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Mueller Ralf,Dawson Eric S.,Meiler Jens,Rodriguez Alice L.,Chauder Brian A.,Bates Brittney S.,Felts Andrew S.,Lamb Jeffrey P.,Menon Usha N.,Jadhav Sataywan B.,Kane Alexander S.,Jones Carrie K.,Gregory Karen J.,Niswender Colleen M.,Conn P. Jeffrey,Olsen Christopher M.,Winder Danny G.,Emmitte Kyle A.,Lindsley Craig W.

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201100510/fullpdf

Reference60 articles.

1. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

2. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

3. Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

4. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

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