Probing lactate metabolism variations in large-scale bioreactors-Reference-Cited by-同舟云学术

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Probing lactate metabolism variations in large-scale bioreactors

Published:2018-03-06 Issue:3 Volume:34 Page:756-766
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Xu Sen¹^ORCID,Jiang Rubin¹,Mueller Roland²,Hoesli Nadja²,Kretz Thomas²,Bowers John³,Chen Hao¹

Affiliation:

1. Upstream Process Development and Engineering, Biologics Process Development & Clinical Manufacturing; Merck & Co., Inc.; Kenilworth NJ

2. Biologics Process Development & Clinical Manufacturing; MSD Werthenstein BioPharma GmbH; Schachen Switzerland

3. Bioprocess Technical Operations, Biologics Process Development & Clinical Manufacturing; Merck & Co., Inc.; Kenilworth NJ

Publisher

Wiley

Subject

Biotechnology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/btpr.2620/fullpdf

Reference55 articles.

1. Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture;Templeton;Biotechnol Bioeng.,2013

2. Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases;Zhou;J Biotechnol.,2011

3. Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK;Rodrigues;Biotechnol Bioeng.,2016

4. Metabolic engineering of CHO cells to alter lactate metabolism during fed-batch cultures;Toussaint;J Biotechnol.,2016

5. Multivariate analysis of cell culture bioprocess data-Lactate consumption as process indicator;Le;J Biotechnol.,2012

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1. Building blocks needed for mechanistic modeling of bioprocesses: A critical review based on protein production by CHO cells;Metabolic Engineering Communications;2024-06

2. Exploring metabolic responses and pathway changes in CHO‐K1 cells under varied aeration conditions and copper supplementations using ¹H NMR‐based metabolomics;Biotechnology Journal;2024-02

3. Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior;Biotechnology and Bioengineering;2024-01-08

4. Scale‐up analysis of geometrically dissimilar single‐use bioreactors;Biotechnology and Bioengineering;2023-08-22

5. Recent advances in in-vitro meat production;Annals of Animal Science;2023-05-25

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