Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK-Reference-Cited by-同舟云学术

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Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK

Published:2015-09-02 Issue:1 Volume:113 Page:150-162
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnol. Bioeng.

Author:

Rodrigues A. F.¹²,Guerreiro M. R.¹²,Formas-Oliveira A. S.¹²,Fernandes P.¹²,Blechert A.-K.³,Genzel Y.³,Alves P. M.¹²,Hu W. S.⁴,Coroadinha A. S.¹²

Affiliation:

1. Instituto de Biologia Experimental e Tecnológica; Apartado 12, 2781-901 Oeiras; Portugal

2. Instituto de Tecnologia Química e Biológica; Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras; Portugal

3. Max Planck Institute for Dynamics of Complex Technical Systems; Bioprocess Engineering Group, Magdeburg; Germany

4. Department of Chemical Engineering and Materials Science; University of Minnesota; Minneapolis USA

Funder

Fundação Para a Ciência e a Tecnologia (FCT)

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference37 articles.

1. Strategies for fed-batch cultivation of t-PA producing CHO cells: Substitution of glucose and glutamine and rational design of culture medium;Altamirano;J Biotechnol,2004

2. Improving baculovirus production at high cell density through manipulation of energy metabolism;Carinhas;Metab Eng,2010

3. The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases;Caspi;Nucleic Acids Res,2010

4. Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures;Chee Furng Wong;Biotechnol Bioeng,2005

5. Retrovirus producer cell line metabolism: Implications on viral productivity;Coroadinha;Appl Microbiol Biotechnol,2006a

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3. Investigating dynamics of lentiviral vector secretion from HEK293T producer cells using a fractionated perfusion system;Biotechnology Journal;2023-09-21

4. Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes;Cells;2021-07-02

5. Overexpression of ER Protein Processing and Apoptosis Regulator Genes in Human Embryonic Kidney 293 Cells Improves Gene Therapy Vectors Production;Biotechnology Journal;2020-07-26

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