Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin-Reference-Cited by-同舟云学术

Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Published:2020-11-28 Issue:4 Volume:109 Page:1063-1073
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Sou Tomás¹,Hansen Jon²,Liepinsh Edgars³,Backlund Maria⁴,Ercan Onur⁵,Grinberga Solveiga³,Cao Sha⁵,Giachou Paraskevi⁵,Petersson Anna⁵,Tomczak Magdalena⁶,Urbas Malgorzata⁶,Zabicka Dorota⁶,Vingsbo Lundberg Carina²,Hughes Diarmaid⁵,Hobbie Sven N.⁷,Friberg Lena E.¹

Affiliation:

1. Pharmacometrics Department of Pharmacy Uppsala University Uppsala Sweden

2. Department of Bacteria, Parasites and Fungi Statens Serum Institute Copenhagen Denmark

3. Latvian Institute of Organic Synthesis Riga Latvia

4. Department of Pharmacy Uppsala University Drug Optimization and Pharmaceutical Profiling Uppsala University Uppsala Sweden

5. Department of Medical Biochemistry and Microbiology Uppsala University Uppsala Sweden

6. Department of Epidemiology and Clinical Microbiology National Medicines Institute Warsaw Poland

7. Institute of Medical Microbiology University of Zurich Zurich Switzerland

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2104

Reference44 articles.

1. Aminoglycosides: An Overview

2. Antibiotics that target protein synthesis

3. In vitro Apramycin Activity against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa

4. Evaluation of apramycin activity against carbapenem-resistant and -susceptible strains of Enterobacteriaceae

5. Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: An update

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