Biomarker discovery and metabolic profiling in serum of cardiovascular disease patients with untargeted metabolomics and machine learning

Author:

Shen Xia123,Guo Shuyuan13,Liang Ningning14,Zhao Mingming5,Wang Chun5,Li Zi1,Yan Dewen6,Zheng Lemin578,Yin Huiyong134ORCID

Affiliation:

1. CAS Key Laboratory of Nutrition, Metabolism, and Food Safety Shanghai Institute of Nutrition and Health Chinese Academy of Sciences (CAS) Shanghai China

2. University of Chinese Academy of Sciences Beijing China

3. School of Life Science and Technology ShanghaiTech University Shanghai China

4. Department of Biomedical Sciences The Tung Biomedical Sciences Centre Jockey Club College of Veterinary Medicine and Life Sciences State Key Laboratory of Marine Pollution (SKLMP) The Shenzhen Research Institute and Futian Research Institute City University of Hong Kong Hong Kong China

5. School of Basic Medical Sciences The Institute of Cardiovascular Sciences State Key Laboratory of Vascular Homeostasis and Remodeling NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing Key Laboratory of Cardiovascular Receptors Research Health Science Center Peking University Beijing China

6. Department of Endocrinology Shenzhen Second People's Hospital the First Affiliated Hospital of Shenzhen University Health Science Center of Shenzhen University Shenzhen Clinical Research Center for Metabolic Diseases Shenzhen Center for Diabetes Control and Prevention Shenzhen Guangdong China

7. Beijing Tiantan Hospital China National Clinical Research Center for Neurological Diseases Advanced Innovation Center for Human Brain Protection The Capital Medical University Beijing China

8. School of Basic Medical Sciences The Institute of Systems Biomedicine Health Science Center Peking University Beijing China

Funder

Science and Technology Commission of Shanghai Municipality

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

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