Synthesis, Biological Evaluation, and Molecular Docking of Novel Thiazoles and [1,3,4]Thiadiazoles Incorporating Sulfonamide Group as DHFR Inhibitors-Reference-Cited by-同舟云学术

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Synthesis, Biological Evaluation, and Molecular Docking of Novel Thiazoles and [1,3,4]Thiadiazoles Incorporating Sulfonamide Group as DHFR Inhibitors

Published:2018-08-16 Issue:9 Volume:15 Page:e1800231
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chem Biodiversity

Author:

Riyadh Sayed M.¹²,El-Motairi Shojaa A.¹,Ahmed Hany E. A.³⁴,Khalil Khaled D.¹²,Habib EL-Sayed E.⁵⁶

Affiliation:

1. Department of Chemistry; Faculty of Science; Taibah University; Al-Madinah Al-Munawaraha 30002 Saudi Arabia

2. Department of Chemistry; Faculty of Science; Cairo University; Giza 12613 Egypt

3. Pharmacognosy and Pharmaceutical Chemistry Department; Pharmacy College; Taibah University; Al-Madinah Al-Munawaraha 41477 Saudi Arabia

4. Pharmaceutical Organic Chemistry Department; Faculty of Pharmacy; Al-Azhar University; Cairo 11884 Egypt

5. Pharmaceutics and Pharmaceutical Technology Department; College of Pharmacy; Taibah University; Al-Madinah Al-Munawaraha 41477 Saudi Arabia

6. Microbiology Department; Faculty of Pharmacy; Mansoura University; Mansoura 35516 Egypt

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cbdv.201800231/fullpdf

Reference52 articles.

1. Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase;Schnell;Annu. Rev. Biophys. Biomol. Struct.,2004

2. Design and Synthesis of Small Molecular Dual Inhibitor of Falcipain-2 and Dihydrofolate Reductase as Antimalarial Agent;Huang;Bioorg. Med. Chem. Lett.,2012

3. Insights Into the Slow-onset Tight-binding Inhibition of Escherichia coli Dihydrofolate Reductase: Detailed Mechanistic Characterization of pyrrolo[3,2-f]quinazoline-1,3-diamine and Its Derivatives as Novel Tight-binding Inhibitors;Srinivasan;FEBS J.,2015

4. Ligand Binding Studies, Preliminary Structure-activity Relationship and Detailed Mechanistic Characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine Derivatives as Inhibitors of Escherichia coli Dihydrofolate Reductase;Srinivasan;Eur. J. Med. Chem.,2015

5. Discovery of 4-Aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of in Vitro Potencies and Pharmacokinetic Properties;Lee;J. Med. Chem.,2014

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4. New Pyrazole-Clubbed Pyrimidine or Pyrazoline Hybrids as Anti-Methicillin-Resistant Staphylococcus aureus Agents: Design, Synthesis, In Vitro and In Vivo Evaluation, and Molecular Modeling Simulation;ACS Omega;2023-11-09

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