Insights into the slow-onset tight-binding inhibition ofEscherichia colidihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors-Reference-Cited by-同舟云学术

Insights into the slow-onset tight-binding inhibition ofEscherichia colidihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors

Published:2015-03-06 Issue:10 Volume:282 Page:1922-1938
ISSN:1742-464X
Container-title:FEBS Journal
language:en
Short-container-title:FEBS J

Author:

Srinivasan Bharath¹,Skolnick Jeffrey¹

Affiliation:

1. Center for the Study of Systems Biology; Georgia Institute of Technology; Atlanta GA USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/febs.13244/fullpdf

Reference37 articles.

1. Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: temporal order and the roles of Asp27 and Tyr100;Liu;Proc Natl Acad Sci USA,2014

2. Dihydrofolate reductase as a therapeutic target;Schweitzer;FASEB J,1990

3. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence;Sawaya;Biochemistry,1997

4. Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli;Fierke;Biochemistry,1987

5. Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase;Cayley;Biochemistry,1981

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