Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure‐Selectivity Relationship of a Ketoreductase-Reference-Cited by-同舟云学术

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Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure‐Selectivity Relationship of a Ketoreductase

Published:2019-03 Issue:9 Volume:20 Page:1150-1154
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Häckh Matthias¹,Lucas Xavier¹²^ORCID,Marolt Marija¹,Leadlay Peter F.³^ORCID,Müller Michael¹^ORCID,Günther Stefan¹^ORCID,Lüdeke Steffen¹^ORCID

Affiliation:

1. Institute of Pharmaceutical SciencesUniversity of Freiburg Albertstrasse 25 79104 Freiburg Germany

2. Present addressRoche Pharma Research and Early DevelopmentRoche Innovation Center 4070 Basel Switzerland

3. Department of BiochemistryUniversity of Cambridge 80 Tennis Court Road Cambridge CB2 1GA UK

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.201800799

Reference28 articles.

1. A fungal ketoreductase domain that displays substrate-dependent stereospecificity

2.

3. Steric Effects on the Stereochemistry of Old Yellow Enzyme-Mediated Reductions of Unsaturated Diesters: Flipping of the Substrate within the Enzyme Active Site Induced by Structural Modifications

4. Asymmetric Bioreduction of CC Bonds using Enoate Reductases OPR1, OPR3 and YqjM: Enzyme-Based Stereocontrol

5. Origins of stereoselectivity in evolved ketoreductases

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1. Synthesis of Biomimetic Thioesters for Studies of Ketoreductase Domains from the Biosynthesis of Cytotoxic Polyketides;Synlett;2023-11-22

2. Studying a Bottleneck of Multimodular Polyketide Synthase Processing: the Polyketide Structure-Dependent Performance of Ketoreductase Domains;ACS Chemical Biology;2022-04-12

3. SeMPI 2.0—A Web Server for PKS and NRPS Predictions Combined with Metabolite Screening in Natural Product Databases;Metabolites;2020-12-29

4. Site‐Directed Mutagenesis of Modular Polyketide Synthase Ketoreductase Domains for Altered Stereochemical Control;ChemBioChem;2020-12-22

5. Step-Economic Synthesis of Biomimetic β-Ketopolyene Thioesters and Demonstration of Their Usefulness in Enzymatic Biosynthesis Studies;Organic Letters;2020-06-17

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