Pre-incisional intraparietal injection of cephamandole: A new approach to wound infection prophylaxis

Author:

Armstrong C P1,Taylor T V1,Reeves D S2

Affiliation:

1. University Department of Clinical Surgery, Edinburgh Royal Infirmary, Edinburgh EH39YW, Scotland

2. Southmead Hospital, Bristol, England

Abstract

Abstract Pre-incisional injection of cephamandole has been studied. Wound tissue levels of cephamandole have been found to be extremely high throughout the operation. Serum levels were comparable to those obtained with parenterally administered antibiotic. The use of a pre-incisional injection of antibiotic therefore offers major theoretical advantages over the use of either conventional parenteral or topical antibiotics in the prevention of postoperative sepsis.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference10 articles.

1. Cefamandole: in vitro and clinical pharmacokinetics;Griffith;Antimicrob. Agents Chemother.,1976

2. The proper use of local antimicrobial agents in wounds;Moylan;World J. Surg.,1980

3. The effect of an antibiotic spray in the prevention of wound infection;Jackson;Br. J. Surg.,1971

4. Postoperative wound infection a computer analysis;Davidson;Br. J. Surg.,1971

5. Postoperative wound infections: a prospective study of determinant factors and prevention;Polk;Surgery,1969

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