Affiliation:
1. Lilly Laboratory for Clinical Research, Wishard Memorial Hospital, Indianapolis, Indiana 46202
Abstract
Cefamandole has a broader spectrum and greater potency than the other cephalosporins. It includes
Haemophilus influenzae
, most strains of
Enterobacter
, and many strains of indole-positive
Proteus
and
Bacteroides
, with a lower minimal inhibitory concentration for
Escherichia coli, Klebsiella
, etc. Concentrations of drug in the serum after the parenteral injection of cefamandole exceed manyfold the minimal inhibitory concentrations of over 82% of the bacteria studied. Approximately 65 to 85% is excreted in a biologically active form in the urine. This antibiotic offers advantages of antibacterial effectiveness and at the same time retains the safety of penicillin G and cephalothin in animals.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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