Wound infection after metronidazole infiltration

Author:

Bhargava Pranshu1,Mehrotra Nidhi,Kumar Ajay

Affiliation:

1. Department of Surgery & Pediatric Surgery, Lady Hardinge Medical College & Assoc., Smt Sucheta Kriplani Hospital, New Delhi 110001, India

Abstract

In state-run hospitals in India, pre-existing malnutrition and anaemia with late presentation, septicaemia and gross peritoneal contamination lead to a very high wound infection rate despite the use of systemic antibiotics. We studied the wound infection rate of subcutaneous infiltration of metronidazole (group B) versus irrigation with saline (group A) in patients undergoing exploratory laprotomy for perforation peritonitis with pyoperitoneum. The study included 30 patients in group A and 30 in group B. In group A 66.6% of the patients developed wound infection, whereas in group B 26.6% only developed wound infection. This difference is found to be statistically significant at a level of P < 0.01. There was no local complication attributable to infiltration of metronidazole in group B. Thus, we concluded that local infiltration of metronidazole at the incision is a safe and effective measure to control wound infection in cases of perforation peritonitis with pyoperitoneum.

Publisher

SAGE Publications

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Incisional Wound Irrigation for the Prevention of Surgical Site Infection;JAMA Surgery;2024-07-01

2. Intracavity lavage and wound irrigation for prevention of surgical site infection;Cochrane Database of Systematic Reviews;2017-10-30

3. Prevention of Surgical Site Infections and Biofilms;Plastic and Reconstructive Surgery - Global Open;2017-05

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