Affiliation:
1. Department of Chemistry University of Wisconsin-Madison 1101 University Ave. Madison WI 53706 USA
2. Scioto Biosciences Inc., 1800 N. Capitol Ave. Indianapolis IN 46202
Abstract
AbstractStaphylococcus aureus is a ubiquitous bacterium that has become a major threat to human health due to its extensive toxin production and tremendous capacity for antibiotic resistance (e. g., MRSA “superbug” infections). Amid a worsening antibiotic resistance crisis, new strategies to combat this deadly microbe that remove the selective pressure of traditional approaches are in high demand. S. aureus utilizes an accessory gene regulator (agr) quorum sensing network to monitor its local cellular population and trigger a devastating communal attack, like an invading horde, once a threshold cell density has been reached. The role of the agr system in a range of disease types is still being unraveled. Herein, we discuss the present‐day biochemical understanding of agr along with unresolved details, describe its connection to the progression of infection, and review how chemical strategies have been implemented to study and intercept this signaling pathway. This research is illuminating the potential of agr as an anti‐virulence target in S. aureus and should inform the study of similar, yet less studied, agr systems in related bacterial pathogens.
Funder
National Science Foundation
National Institutes of Health
Cited by
4 articles.
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