Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes

Author:

Gorris Raphaela1,Fischer Julia1,Erwes Kim Lina1,Kesavan Jaideep1,Peterson Daniel A.12,Alexander Michael3,Nöthen Markus M.3,Peitz Michael14,Quandel Tamara1,Karus Michael1,Brüstle Oliver1

Affiliation:

1. Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn; Germany

2. Center for Stem Cell and Regenerative Medicine, Department of Neuroscience, Rosalind Franklin University of Medicine and Science; Chicago Illinois

3. Institute of Human Genetics, LIFE & BRAIN Center, University of Bonn; Germany

4. German Center for Neurodegenerative Diseases; Bonn Germany

Funder

California Institute of Regenerative Medicine and the BMBF (RFA 10-01 CIRM Early Translational II Research Awards; VDI)

German Federal Ministry of Education and Research (BMBF)

German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding concept

BIO.NRW (project StemCellFactory)

SCR & Tox consortium

European Commission within its FP7 Programme and COLIPA, the European Cosmetics Association, as part of the SEURAT-1 cluster, and Hertie Foundation

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Neurology

Reference78 articles.

1. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation;Aubert;Nat Biotechnol,2002

2. Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture;Bain;Biochem Biophys Res Commun,1996

3. Fine-tuning oligodendrocyte development by microRNAs;Barca-Mayo;Front Neurosci,2012

4. Differentiation of mouse embryonic stem cells into a defined neuronal lineage;Bibel;Nat Neurosci,2004

5. Generation and characterization of oligodendrocytes from lineage-selectable embryonic stem cells in vitro;Billon;Methods Mol Biol,2006

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