Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position-Reference-Cited by-同舟云学术

Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position

Published:2020-02-17 Issue:4 Volume:36 Page:
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Carver Joe¹,Ng Domingos¹,Zhou Michelle¹,Ko Peggy¹,Zhan Dejin¹,Yim Mandy¹,Shaw David¹^ORCID,Snedecor Brad¹,Laird Michael W.¹,Lang Steven¹,Shen Amy¹^ORCID,Hu Zhilan¹^ORCID

Affiliation:

1. Department of Cell CultureGenentech, Inc. South San Francisco California USA

Publisher

Wiley

Subject

Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.2967

Reference33 articles.

1. Generation of monoclonal antibody-producing mammalian cell lines

2. Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined φC31 integrase and CRE-Lox technologies

3. Recombinant protein expression by targeting pre-selected chromosomal loci

4. Towards rational engineering of cells: Recombinant gene expression in defined chromosomal loci

5. Recombinase-mediated cassette exchange (RMCE) for monoclonal antibody expression in the commercially relevant CHOK1SV cell line

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