Recombinase-mediated cassette exchange (RMCE) for monoclonal antibody expression in the commercially relevant CHOK1SV cell line-Reference-Cited by-同舟云学术

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Recombinase-mediated cassette exchange (RMCE) for monoclonal antibody expression in the commercially relevant CHOK1SV cell line

Published:2015-10-13 Issue:6 Volume:31 Page:1645-1656
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Zhang Lin¹,Inniss Mara C.¹,Han Shu¹,Moffat Mark²,Jones Heather²,Zhang Baohong³,Cox Wendy L.⁴,Rance James R.⁵,Young Robert J.⁶

Affiliation:

1. Cell Line Development, World Wide Pharmaceutical Sciences; BioTherapeutics Research and Development, Pfizer Inc.; Andover MA 01810

2. Cell Line Development, World Wide Pharmaceutical Sciences; BioTherapeutics Research and Development, Pfizer Inc.; Chesterfield MO 63017

3. BioTX Clinical Research, Pfizer Inc.; Cambridge MA 02140

4. Cell Culture Development, Lonza Biologics; Slough SL1 4DX U.K.

5. Development Services Singapore, Lonza Biologics Tuas Pte Ltd; Singapore

6. New Expression Technologies Group, Research & Technology, Lonza Biologics; Granta Park, Great Abington, Cambridge CB21 6GS U.K.

Publisher

Wiley

Subject

Biotechnology

Reference38 articles.

1. Intraclonal protein expression heterogeneity in recombinant CHO cells;Pilbrough;PloS One.,2009

2. Stability of protein production from recombinant mammalian cells;Barnes;Biotechnol Bioeng.,2003

3. Stochastic mRNA synthesis in mammalian cells;Raj;PLoS Biol.,2006

4. Cytogenetic analysis of chimeric antibody-producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure;Kim;Biotechnol Bioeng.,1999

5. Evaluation of stable and highly productive gene amplified CHO cell line based on the location of amplified genes;Yoshikawa;Cytotechnology.,2000

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