Capecitabine-based treatment of a patient with a novelDPYDgenotype and complete dihydropyrimidine dehydrogenase deficiency

Author:

Henricks Linda M.1ORCID,Siemerink Ester J.M.2,Rosing Hilde3,Meijer Judith4,Goorden Susan M.I.4,Polstra Abeltje M.45,Zoetekouw Lida4,Cats Annemieke6,Schellens Jan H.M.17,van Kuilenburg André B.P.4

Affiliation:

1. Division of Pharmacology and Division of Clinical Pharmacology, Department of Medical Oncology; The Netherlands Cancer Institute; Amsterdam The Netherlands

2. Department of Internal Medicine; Ziekenhuis Groep Twente (ZGT); Hengelo The Netherlands

3. Department of Pharmacy and Pharmacology; The Netherlands Cancer Institute; Amsterdam The Netherlands

4. Laboratory Genetic Metabolic Diseases, Departments of Clinical Chemistry and Clinical Genetics; Academic Medical Center, University of Amsterdam; Amsterdam The Netherlands

5. Department of Clinical Genetics; VU University Medical Center; Amsterdam The Netherlands

6. Department of Gastrointestinal Oncology; The Netherlands Cancer Institute; Amsterdam The Netherlands

7. Utrecht Institute for Pharmaceutical Sciences, Utrecht University; Utrecht The Netherlands

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference25 articles.

1. Clinical pharmacology of 5-fluorouracil;Diasio;Clin Pharmacokinet,1989

2. Population study of dihydropyrimidine dehydrogenase in cancer patients;Etienne;J Clin Oncol,1994

3. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy;Lu;Cancer Res,1993

4. Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data;Meulendijks;Lancet Oncol,2015

5. Clinical pharmacogenetics implementation consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing;Caudle;Clin Pharmacol Ther,2013

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