Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants

Author:

van Kuilenburg André B.P.1ORCID,Pleunis-van Empel Marjolein C.H.2,Brouwer Rick B.3,Sijben Angelique E.J.4,Knapen Daan G.5ORCID,Oude Munnink Thijs H.6ORCID,van Zanden Jelmer J.7,Janssens-Puister Jenny8,Dobritzsch Doreen9,Meinsma Rutger1,Meijer-Jansen Judith1,van Dooren Silvy J.M.1,Vijzelaar Raymon10,Pop Ana1,Salomons Gajja S.1ORCID,Maring Jan Gerard11ORCID,Niezen-Koning Klary E.8ORCID

Affiliation:

1. Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands

2. Medisch Spectrum Twente, Department of Oncology, Enschede, the Netherlands

3. Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Medlon BV, Enschede, the Netherlands

4. Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands

5. Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

6. Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands

7. Martini Hospital Groningen, Certe Department of Clinical Chemistry, the Netherlands

8. Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

9. Department of Chemistry, Uppsala University, Biomedical Center, Uppsala, Sweden

10. MRC-Holland bv, Amsterdam, the Netherlands

11. Departments of Clinical Pharmacy and Medical Oncology, Isala, Zwolle, the Netherlands

Abstract

A DPD deficiency should be considered in case of severe toxicity even in the absence of common risk variants in DPYD.

Publisher

American Society of Clinical Oncology (ASCO)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Reply to: “Is uracil enough for effective pre-emptive DPD testing?”;Clinical Chemistry and Laboratory Medicine (CCLM);2024-08-15

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3