Is uracil enough for effective pre-emptive DPD testing?
Author:
Affiliation:
1. Department of Clinical Chemistry , Erasmus University Medical Center , Rotterdam , The Netherlands
2. Department of Medical Oncology , Erasmus MC Cancer Institute, Erasmus University Medical Center , Rotterdam , The Netherlands
Publisher
Walter de Gruyter GmbH
Link
https://www.degruyter.com/document/doi/10.1515/cclm-2024-0742/pdf
Reference7 articles.
1. Launay, M, Raymond, L, Guitton, J, Loriot, MA, Chatelut, E, Haufroid, V, et al.. Can we identify patients carrying targeted deleterious DPYD variants with plasma uracil and dihydrouracil? A GPCO-RNPGx retrospective analysis. Clin Chem Lab Med 2024. https://doi.org/10.1515/cclm-2024-0317 [Epub June 19, 2024].
2. Meulendijks, D, Henricks, LM, Sonke, GS, Deenen, MJ, Froehlich, TK, Amstutz, U, et al.. Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data. Lancet Oncol 2015;16:1639–50. https://doi.org/10.1016/s1470-2045(15)00286-7.
3. Henricks, LM, Lunenburg, CATC, de Man, FM, Meulendijks, D, Frederix, GWJ, Kienhuis, E, et al.. DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis. Lancet Oncol 2018;19:1459–67. https://doi.org/10.1016/s1470-2045(18)30686-7.
4. Thomas, F, Hennebelle, I, Delmas, C, Lochon, I, Dhelens, C, Garnier Tixidre, C, et al.. Genotyping of a family with a novel deleterious DPYD mutation supports the pretherapeutic screening of DPD deficiency with dihydrouracil/uracil ratio. Clin Pharmacol Ther 2016;99:235–42. https://doi.org/10.1002/cpt.210.
5. Henricks, LM, Kienhuis, E, de Man, FM, van der Veldt, AAM, Hamberg, P, van Kuilenburg, ABP, et al.. Treatment algorithm for homozygous or compound heterozygous DPYD variant allele carriers with low-dose capecitabine. JCO Precis Oncol 2017;1:1–10. https://doi.org/10.1200/po.17.00118.
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1. Reply to: “Is uracil enough for effective pre-emptive DPD testing?”;Clinical Chemistry and Laboratory Medicine (CCLM);2024-08-15
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