Time-Dependent Inhibition and Induction of Human Cytochrome P4503A4/5 by an Oral IAP Antagonist, LCL161, In Vitro and In Vivo in Healthy Subjects
Author:
Affiliation:
1. Novartis Pharmaceuticals Corporation; East Hanover, NJ; USA
2. Novartis Institutes for Biomedical Research; East Hanover, NJ; USA
3. Novartis Pharmaceuticals Corporation; Cambridge, MA; USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/jcph.79/fullpdf
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3. A smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling;Gaither;Cancer Res.,2007
4. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis;Varfolomeev;Cell.,2007
5. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis;Vince;Cell.,2007
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