Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches
Author:
Affiliation:
1. UCB, Avenue de l’Industrie, Braine-L’Alleud 1420, Belgium
2. UCB, 216 Bath Road, Slough, SL1 3WE, U.K.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02245
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1. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
2. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
3. SXR, a novel steroid and xenobioticsensing nuclear receptor
4. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
5. Chrysin Ameliorates Chemically Induced Colitis in the Mouse through Modulation of a PXR/NF-κB Signaling Pathway
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