Cysteine in cell culture media induces acidic IgG1 species by disrupting the disulfide bond network-Reference-Cited by-同舟云学术

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Cysteine in cell culture media induces acidic IgG1 species by disrupting the disulfide bond network

Published:2020-12-16 Issue:3 Volume:118 Page:1091-1104
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Prade Elke¹,Zeck Anne²,Stiefel Fabian³,Unsoeld Andreas³,Mentrup David¹,Arango Gutierrez Erik¹,Gorr Ingo H.¹^ORCID

Affiliation:

1. Early Stage Bioprocess Development, Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany

2. Pharma and Biotech, NMI Natural and Medical Sciences Institute University of Tübingen Reutlingen Germany

3. Late Stage USP Development, Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany

Funder

Boehringer Ingelheim

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27628

Reference48 articles.

1. Multi‐Omics Study on the Impact of Cysteine Feed Level on Cell Viability and mAb Production in a CHO Bioprocess

2. Three-Dimensional Structure of Immunoglobulins

3. Removal of Cysteinylation from an Unpaired Sulfhydryl in the Variable Region of a Recombinant Monoclonal IgG1 Antibody Improves Homogeneity, Stability, and Biological Activity

4. Intrachain disulfide bond in the core hinge region of human IgG4. Protein science: A publication of the Protein;Bloom J. W.;Society,1997

5. Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

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