Multi‐Omics Study on the Impact of Cysteine Feed Level on Cell Viability and mAb Production in a CHO Bioprocess
Author:
Affiliation:
1. Cell Culture Development, Biogen, Inc.CambridgeMA02142USA
2. Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University360 Huntington Ave.BostonMA02115USA
3. Analytical Development, Biogen, Inc.CambridgeMA02142USA
Publisher
Wiley
Subject
Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.201800352
Reference64 articles.
1. 25 years of recombinant proteins from reactor-grown cells — Where do we go from here?
2. Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment
3. Identifying and eliminating cell culture process variability
4. Glutathione Metabolism and Its Implications for Health
Cited by 34 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism;Metabolic Engineering;2024-09
2. RNASeq highlights ATF6 pathway regulators for CHO cell engineering with different impacts of ATF6β and WFS1 knockdown on fed-batch production of IgG1;Scientific Reports;2024-06-19
3. Acidic Derivatization of Thiols Using Diethyl 2-Methylenemalonate: Thiol-Michael Addition Click Reaction for Simultaneous Analysis of Cysteine and Cystine in Culture Media Using LC–MS/MS;Analytical Chemistry;2024-04-09
4. The potential of Rhodobacter sphaeroides extract as an alternative supplement for cell culture systems;Microbiology Spectrum;2024-03-05
5. Exploring metabolic responses and pathway changes in CHO‐K1 cells under varied aeration conditions and copper supplementations using 1H NMR‐based metabolomics;Biotechnology Journal;2024-02
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3