Removal of Cysteinylation from an Unpaired Sulfhydryl in the Variable Region of a Recombinant Monoclonal IgG1 Antibody Improves Homogeneity, Stability, and Biological Activity-Reference-Cited by-同舟云学术

Removal of Cysteinylation from an Unpaired Sulfhydryl in the Variable Region of a Recombinant Monoclonal IgG1 Antibody Improves Homogeneity, Stability, and Biological Activity

Published:2008-02 Issue:2 Volume:97 Page:775-790
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Banks Douglas D.,Gadgil Himanshu S.,Pipes Gary D.,Bondarenko Pavel V.,Hobbs Vipa,Scavezze Joanna L.,Kim Jun,Jiang Xu-Rong,Mukku Venkat,Dillon Thomas M.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference23 articles.

1. Monoclonal antibody successes in the clinic;Reichert;Nat biotechnol,2005

2. Characterizing biological products and assessing comparability following manufacturing changes;Chirino;Nat biotechnol,2004

3. Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis;Gadgil;Anal Biochem,2006

4. The covalent structure of an entire gammaG immunoglobulin molecule;Edelman;Proc Natl Acad Sci USA,1969

5. An immunoglobulin light chain of subgrou pof lambda type with a free sulfhydryl group;Buchwald;Can J Biochem,1971

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