Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity-Reference-Cited by-同舟云学术

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Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity

Published:2023-09-24 Issue:1 Volume:15 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Lietz Christopher B.¹,Deyanova Ekaterina²,Cho Younhee³,Cordia Jon³,Franc Sarah³,Kabro Sally³,Wang Steven³,Mikolon David⁴,Banks Douglas D.³

Affiliation:

1. Department of Pharmaceutical Candidate Optimization - DMPK, Bristol Myers Squibb, San Diego, CA, USA

2. Department of Pharmaceutical Candidate Optimization - DPAS, Bristol Myers Squibb, Lawrenceville, NJ, USA

3. Department of Pharmaceutical Candidate Optimization - DPAS, Bristol Myers Squibb, San Diego, CA, USA

4. Department of Biotherapeutics, Bristol Myers Squibb, San Diego, CA, USA

Funder

no funding associated with the work

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2023.2259289

Reference41 articles.

1. Monoclonal Antibody "Gold Rush"

2. Small molecules for small minds? The case for biologic pharmaceuticals

3. Next generation antibody drugs: pursuit of the 'high-hanging fruit'

4. Structure-Immunogenicity Relationships of Therapeutic Proteins

5. A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals

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1. Developing Analytical ion Exchange Chromatography Methods for Antibody Drug Conjugates Containing the Hydrolysis-Prone Succinimide-Thioether Conjugation Chemistry;Journal of Pharmaceutical Sciences;2024-08

2. Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity assessment;mAbs;2024-07-02

3. Structure-function relationship study for sulfated protein therapeutics using hydrophobic interaction chromatography and mass spectrometry;Journal of Chromatography B;2024-02

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