Natural Multifunctional Silk Microcarriers for Noise‐Induced Hearing Loss Therapy

Author:

Zhang Hui123,Chen Hong2,Lu Ling2,Wang Huan45,Zhao Yuanjin2ORCID,Chai Renjie1367

Affiliation:

1. State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High‐Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 China

2. Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China

3. Co‐Innovation Center of Neuroregeneration Nantong University Nantong 226001 China

4. The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 China

5. Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering Shenzhen University Shenzhen 518060 China

6. Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu 610072 China

7. School of Life Science Beijing Institute of Technology Beijing 100081 China

Abstract

AbstractNoise‐induced hearing loss (NIHL) is a common outcome of excessive reactive oxygen species in the cochlea, and the targeted delivery of antioxidants to the inner ear is a potential therapeutic strategy. In this paper, a novel natural biomaterials‐derived multifunctional delivery system using silk fibroin‐polydopamine (PDA)‐composited inverse opal microcarriers (PDA@SFMCs) is presented for inner ear drug delivery and NIHL therapy. Due to their large specific surface area and interpenetrating nanochannels, PDA@SFMCs can rapidly load active biomolecules making them a convenient medium for the storage and delivery of such molecules. In addition, surface modification of PDA enables the microcarriers to remain in the round window niche, thus facilitating the precise local and directed delivery of loaded drugs. Based on these features, it is demonstrated here that n‐acetylcysteine‐loaded silk microcarriers have satisfactory antioxidant properties on cells and can successfully prevent NIHL in guinea pigs. These results indicate that the natural multifunctional silk microcarriers are promising agents for local inner ear drug delivery in the clinic.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Science and Technology Department of Sichuan Province

Shenzhen Fundamental Research Program

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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