Affiliation:
1. Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, CA 94304, USA
2. Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, CA 94304, USA
3. Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA 94305, USA
Abstract
Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural hearing loss, after age-related hearing loss, and affects approximately 5% of the world’s population. NIHL is associated with substantial physical, mental, social, and economic impacts at the patient and societal levels. Stress and social isolation in patients’ workplace and personal lives contribute to quality-of-life decrements which may often go undetected. The pathophysiology of NIHL is multifactorial and complex, encompassing genetic and environmental factors with substantial occupational contributions. The diagnosis and screening of NIHL are conducted by reviewing a patient’s history of noise exposure, audiograms, speech-in-noise test results, and measurements of distortion product otoacoustic emissions and auditory brainstem response. Essential aspects of decreasing the burden of NIHL are prevention and early detection, such as implementation of educational and screening programs in routine primary care and specialty clinics. Additionally, current research on the pharmacological treatment of NIHL includes anti-inflammatory, antioxidant, anti-excitatory, and anti-apoptotic agents. Although there have been substantial advances in understanding the pathophysiology of NIHL, there remain low levels of evidence for effective pharmacotherapeutic interventions. Future directions should include personalized prevention and targeted treatment strategies based on a holistic view of an individual’s occupation, genetics, and pathology.
Funder
Remondi Foundation
Rich Robbins
Larry Bowman
Bertarelli Foundation Endowed Professorship
Reference320 articles.
1. History and development of hearing protection devices;Acton;J. Acoust. Soc. Am.,1987
2. The worker’s ear: A history of noise-induced hearing loss;Thurston;Am. J. Ind. Med.,2013
3. Institute for Quality and Efficiency in Health Care (IQWiG) (2023, January 25). Hearing Loss and Deafness: Normal Hearing and Impaired Hearing, Available online: https://www.ncbi.nlm.nih.gov/books/NBK390300/.
4. Cardiovascular effects of environmental noise exposure;Gori;Eur. Heart J.,2014
5. World Health Organization (2022, January 10). Deafness and Hearing Loss. Available online: https://www.who.int/news-room/fact-sheets/detail/deafness-and-hearing-loss.
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献